Superantigens are a common link between vaccine injury, animal models of autoimmunity, Long COVID, ME/CFS, and breast implant illness

TL;DR / summary: Vaccine injury may be very similar to autoimmunity induced in lab animals. If we simply read that literature, we can generate treatment ideas that can be tested. (But please don’t do anything crazy on yourself.)

What superantigens are

Antigen definition:

An antigen is any substance that causes your immune system to produce antibodies against it. This means your immune system does not recognize the substance, and is trying to fight it off.

An antigen may be a substance from the environment, such as chemicals, bacteria, viruses, or pollen. An antigen may also form inside the body.

Superantigens are the antigens which trigger your immune system into a hyperactive state.

The way I see it is that the immune system has a ‘superantigen pathway’ or special detectors for superantigens. It goes out of its way to detect superantigens. What it detects are antigens that are stereotypically associated with microbes that can kill you or cause serious health problems.

Gram-negative bacteria usually need to build their cell wall with LPS (Lipopolysaccharide). If it could change the shape of LPS, then it could evade this superantigen-detection system. But most of them can’t do this. LPS is fundamental to how the bacteria work. Because of this, looking for LPS is a reasonable way in which the immune system can tell the difference between foreign proteins in the body (e.g. from a bee sting) and microbes that can multiple can cause problems.

The strategy for fighting proteins and microbes is different. For microbes, bad things can happen if the body does not mount a hyperactive attack against the microbe. Firstly, the microbes can multiply faster than the body can kill it off. That can lead to death. Secondly, the microbes can evolve to become highly adapted to its new environment. This can lead to a persistent infection that the body can never get rid of. We know from Lyme research that many people are able to genocide the bacteria from their body, especially if they are treated early with antibiotics. However, the people who can’t genocide the bacteria from the body often go on to develop very debilitating health problems. This is likely the reason why the immune system has mechanisms that specifically look for superantigens and why the immune system goes into a hyperactive state when superantigens are detected.

Unfortunately, superantigens are known to trigger the development of autoimmune conditions in animal models of human disease. They have been regularly used in disease models to develop drugs such as the Multiple Sclerosis drug Tysabri (natalizumab).

Side note: many scientists see superantigens as toxins

Small amounts of superantigen can kill somebody. It is known to lead to acute health problems such as toxic shock syndrome (wikipedia).

They don’t view the superantigen-detecting abilities of the immune system as something that improves the fitness of an animal. Instead, they characterize superantigens as a toxin.

Superantigens in chronic illness conditions

The SARS-CoV-2 spike protein is a superantigen for humans.

The Lyme vaccines (which were all pulled from the market) have had a poor safety track record and caused Lyme-like symptoms. The vaccines contained superantigens.

Animal models of autoimmune disease (e.g. EAE / experimental autoimmune encephalomyelitis) uses superantigens such as:

  • Dead mycobacteria in Freund’s adjuvant
  • LPS
  • Gardasil - see this censored paper on an animal model of HPV vaccine injury
  • Staphylococcus enterotoxin b

ME/CFS has been linked to outbreaks of enteroviruses. However, it is often argued that it has other triggers such as the Hepatitis B vaccine.

PANDAS, or Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, is linked to streptococcus infections. It’s unclear how similar PANDAS is to vaccine injury.

Long COVID is linked to the virus that makes S1 spike protein, which is a superantigen.


The academic literature talks about certain treatments for EAE, which is autoimmunity triggered by superantigens.

  • HBOT - see this animal study which used pig spinal cord + Freund’s adjuvant
  • Interferon B (mouse interferons used to treat mice). Interferons would explain why Russia/Ukraine use interferon-related drugs like tilorone to treat Multiple Sclerosis.
  • Certain infections will make the sick animals healthier while other infections will make them worse. This may explain why antimicrobials are double-edged swords on the Treatment Outcomes survey.
  • Multiple sclerosis drugs

Hopefully with time we can start reading the scientific literature. This can generate ideas for vaccine injury treatment.

Future research

I don’t know if the S1 spike protein is a superantigen in mice. Research may require genetically-modified mice which see the spike as a superantigen. There have been existing models where the superantigen response has been turned on/off by manipulating the animal’s genetics.

*Disclaimer: Some of the scientific information may be wrong because I haven’t had time to double check it all.